DIAGNOSING PH-ILD

If either routine tests or echo indicate PH, confirm with right heart catheterization (RHC)^2*

Echo findings alone, or lack of clinical suspicion, may not be sufficient in ruling out PH.³ See preliminary results from PHINDER study

RHC Referral Guide

Review this guide to access best practices, clinical guidance, and essential information for referring an RHC.

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*United Therapeutics does not provide medical advice.

RHC is a routine procedure that is the gold standard for diagnosing PH-ILD^4,5

Transplant candidates are required to undergo RHC^4,6

There are few contraindications for RHC^7‡

It can be used to diagnose several other conditions^7§

Low prevalence of serious AEs/complications (1.1%)⁸

RHC is the gold standard that gives you clear answers on PH.^4,5,7,8

^†Clinical suspicion of PH triggers: 1) Signs and symptoms: syncope, jugular venous distension, peripheral edema, ascites, altered heart sounds (especially loud P2 or S2), hepatomegaly, history of pulmonary embolism, dizziness, and palpitations; 2) Standard tests and procedures: abnormalities on chest CT scan, poor oxygen saturation, elevated BNP or NT-proBNP, PFTs, and a reduced 6-min walk distance (6MWD).²

^‡Absolute contraindications for RHC include right-sided endocarditis, tumor, or thrombus; relative contraindications include severe coagulopathy or bleeding diathesis.⁷

^§In patients with dyspnea, RHC can also be used to diagnose or exclude constrictive pericardial disease, restrictive cardiomyopathy, and heart failure with preserved ejection fraction.⁷

AE=adverse event; BNP=B-type natriuretic peptide; CT=computed tomography; ILD=interstitial lung disease; NT-proBNP=N-terminal pro−B-type natriuretic peptide; PFT=pulmonary function test; PH=pulmonary hypertension.