PHINDER STUDY RESULTS

Establishing a path to PH detection

The preliminary results from the PHINDER study show the opportunity of using routine ILD tests often to screen for PH.²

Background & methodology

The PHINDER study is a multicenter, noninterventional, prospective study that aims to identify parameters associated with the presence of PH in ILD and develop a PH detection tool to apply in practice (N=300-350).²

This preliminary analysis is presented to inform current practice, while the final dataset will be used to establish prognostic thresholds and validate a structured screening algorithm.

Inclusion criteria: To enroll, patients must meet ≥1 criterion from ≥2 different enrichment categories based on assessments within 180 days of screening.²*

Noninvasive assessments
An enriched population of patients underwent a broad range of assessments.^2†

Questionnaire
Investigators completed the Investigator’s Suspicion of PH Questionnaire.²

RHC
Patients underwent RHC to confirm precapillary PH.^2‡

This study is preliminary data that should be reviewed with appropriate caution.

Preliminary findings

D_LCO decrease and pulmonary artery enlargement on HRCT may be predictive of PH-ILD^2§

PFT KEY SIGNALS²:

• Decreased D_LCO
• Elevated FVC/D_LCO ratio

HRCT KEY SIGNALS²:

• Elevated PA/aorta ratio
• Elevated RV/LV ratio

Implications: Routine ILD tests can help predict PH.

Compared to RHC, gestalt-based assessments may be inaccurate²

In the PHINDER study, preliminary results showed that RHC confirmed PH in one-third of patients labeled as having a "low likelihood" of PH.²

of patients labeled "low likelihood" to have PH were confirmed to have PH via RHC.²

of gestalt-based assessments were inaccurate compared to RHC.²

*PH-enrichment categories are: 1. PFTs and/or HRCT; 2. Exercise capacity, oxygenation, biomarkers, and/or physical exam; 3. Echocardiography.²

^†Assessments included PFTs, HRCT, exercise capacity, biomarkers, physical exam features, and echocardiography.²

^‡Precapillary PH defined as mPAP >20 mm Hg, PAWP ≤15 mm Hg, and PVR >2 WU.²

^§HRCT and echocardiography imaging were centrally reviewed and interpreted but did not account for inter- or intra-reader variability. The absence of contrast-enhanced HRCT may have limited the precision of vascular measurements.²

^‖Following all noninvasive assessments, investigators were asked to rank their suspicion of PH in each patient as high, medium, or low.²

^¶One patient did not have Investigator's Suspicion of PH reported prior to RHC.²

D_LCO=diffusing capacity of the lung for carbon monoxide; FVC=forced vital capacity; HRCT=high-resolution computed tomography; ILD=interstitial lung disease; LV=left ventricular; mPAP=mean pulmonary arterial pressure; PA=pulmonary artery; PAWP=pulmonary arterial wedge pressure; PFT=pulmonary function test; PH=pulmonary hypertension; PVR=pulmonary vascular resistance; RHC=right heart catheterization; RV=right ventricular; WU=Wood units.