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DISCOVER TYVASO DPI

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FOR US HEALTHCARE PROFESSIONALS ONLY

For the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability.

FOR US HEALTHCARE PROFESSIONALS ONLY

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TRIUMPH OLE

TYVASO showed sustained improvements in 6MWD1

TRIUMPH OLE Study Design: An OLE of the TRIUMPH study to evaluate the safety and dosing of TYVASO over time. Patients (N=206) from the placebo-controlled 12-week TRIUMPH study initiated TYVASO and entered the long-term, uncontrolled OLE study. NYHA FC II (11%), III (86%), IV (3%) at baseline.1,2

IMPROVEMENTS IN 6MWD OVER 18 MONTHS1

Without a control group, data must be interpreted cautiously.

LONG-TERM BENEFITS BEYOND 6MWD1,3

SUSTAINED IMPROVEMENTS IN NYHA FUNCTIONAL CLASS1

maintained or improved NYHA FC from baseline at 2 years (n=120)1,3

36% of patients had improvement in functional class from baseline at 6 months (n=174) and at 2 years (n=120)1,3

90%

SURVIVAL EXCEEDED 80% AT 3 YEARS2

survival rate at 3 years (n=69)2

Based on a long-term follow-up of patients who were treated with TYVASO in the pivotal study and the OLE (Kaplan–Meier estimates of survival).2

82%

These data are from an OLE study. Without a control group, data must be interpreted cautiously.

Safety from the OLE study

  • AEs observed during this chronic dosing study were qualitatively similar to those observed in the 12-week placebo-controlled trial2