TYVASO DPI IS NOW APPROVED

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FOR US HEALTHCARE PROFESSIONALS ONLY

For the treatment of pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3) to improve exercise ability.

FOR US HEALTHCARE PROFESSIONALS ONLY

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FOR US HEALTHCARE PROFESSIONALS ONLY
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SELECT INDICATION

ABOUT PH-ILD

WHAT IS TYVASO?

CLINICAL STUDIES

STARTING TYVASO

RESOURCES & SUPPORT

BENEFITS OF REACHING TARGET DOSE

Help your patients get the most out of TYVASO by achieving the target maintenance dose1

6MWD

Patients receiving a higher dose of TYVASO achieved a 67% greater improvement in 6MWD at 16 weeks1

Patients receiving a higher dose of TYVASO achieved nearly double the improvement in 6MWD at 16 weeksPatients receiving a higher dose of TYVASO achieved nearly double the improvement in 6MWD at 16 weeks

Hodges-Lehmann placebo-corrected median difference.

In the MMRM analysis, patients achieving 10-12 breaths had nearly double the improvement in 6MWD at 16 weeks. Change in 6MWD by dose was a prespecified subgroup analysis.2

Clinical Worsening

Fewer patients in the higher-dose group experienced a clinical worsening event3

The clinical worsening data is a post hoc analysis of data from a prespecified efficacy endpoint.The clinical worsening data is a post hoc analysis of data from a prespecified efficacy endpoint.

Percentage of patients experiencing an event.

The clinical worsening data is a post hoc analysis of data from a prespecified efficacy endpoint. Interpret with appropriate caution.

Our TYVASO Nebulizer Treatment Tracker can help your patients stay on track with their treatment sessions.

Setting your patients up for success

1

Set realistic expectations

  • As the patient titrates to target maintenance dose, they may not see immediate clinical improvements4

Explain importance of reaching target maintenance dose to realize full benefits1

2

Prepare for common AEs

  • Review AEs (eg, cough, headache, and throat irritation) and why they may occur5
  • Give patients specific instructions to proactively manage any AEs that occur
  • Complete AE Management section on the Referral Form

Stress that they should not stop treatment without consulting you

See AE Management Approaches

3

Ensure patients understand the dosing plan

  • With the TYVASO nebulizer, target maintenance dose can be achieved by starting with 3 breaths per session at week 1 and increasing by 1 breath per week until reaching 9-12 breaths per session 1,6
  • With TYVASO DPI, target maintenance dose can be achieved by starting with 16 mcg (1 cartridge) and increasing by 16 mcg at 1- to 2-week intervals to a target maintenance dose of 48 mcg to 64 mcg per treatment session 7
  • Once the target maintenance dose is achieved, the patient should maintain that dose with each treatment session, as tolerated

Emphasize importance of completing all 4 daily treatment sessions

6MWD=6-minute walk distance; AE=adverse event; MMRM=mixed-effect model repeat measurement.

View AE management techniques

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