TYVASO DPI IS NOW APPROVED

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For the treatment of pulmonary hypertension associated with interstitial lung disease (PH-ILD; WHO Group 3) to improve exercise ability.

FOR US HEALTHCARE PROFESSIONALS ONLY

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DOSING & TITRATION

TYVASO has 2 delivery device options—TYVASO DPI and the TYVASO ultrasonic nebulizer. Learn more about the dosing and titration for both options.

 

TYVASO DPI Dosing & Titration

TYVASO DPI is dosed with just 1 breath, 4x daily, approximately every 4 waking hours. Each dose is inhaled in less than 2 seconds.1,2

Dose comparison1

Patients currently using the TYVASO nebulizer can be switched to the corresponding dose of TYVASO DPI:

TYVASO DPI Cartridge Strength
TYVASO Nebulizer # of Breaths


16 mcg

≤5


32 mcg

6 to 7


48 mcg

8 to 10


64 mcg

11 to 12

Titration with TYVASO DPI1

TYVASO DPI titration schedule.

TYVASO DPI titration schedule.

Titration schedules may vary based on tolerability. If the prescribed dose is higher than 64 mcg per treatment session, more than 1 cartridge will be needed per session.1

 

TYVASO Nebulizer Dosing & Titration

Titrate gradually to achieve target maintenance dose3,4

TYVASO titration schedule

TYVASO titration schedule

75% of patients reached ≥9 breaths during the INCREASE study3

Median breaths per session over the course of the study4

Median breaths per session over the course of the INCREASE study
Median breaths per session over the course of the INCREASE study

DPI=dry powder inhaler.