DOSING & TITRATION

Help your patients get the most out of TYVASO® by achieving the target maintenance dose1

Titrate gradually to achieve target maintenance dose1,2

Titrate TYVASO gradually to achieve target maintenance doseTitrate TYVASO gradually to achieve target maintenance dose

75% of patients reached ≥9 breaths during the study1

Median breaths per session over the course of the study2

Median breaths per session over the course of the INCREASE studyMedian breaths per session over the course of the INCREASE study

Patients receiving a higher dose of TYVASO achieved a 67% greater improvement in 6MWD at 16 weeks1*

Patients receiving a higher dose of TYVASO achieved nearly double the improvement in 6MWD at 16 weeksPatients receiving a higher dose of TYVASO achieved nearly double the improvement in 6MWD at 16 weeks

58% of patients achieved 10-12 breaths during the study.3

*Hodges-Lehmann placebo-corrected LS median difference. In the MMRM analysis, patients achieving 10-12 breaths had nearly double the improvement in 6MWD at 16 weeks.4

Our TYVASO Treatment Tracker can help your patients stay on track with their treatment sessions.

Setting your patients up for success

1

Set realistic expectations

  • As the patient titrates to target maintenance dose, they may not see immediate clinical improvements5

2

Prepare for common AEs

  • Review AEs (eg, cough, headache, and throat irritation) and why they may occur3
  • Give patients specific instructions to proactively manage any AEs that occur 
  • Complete AE Management section on the Referral Form

3

Ensure patients understand the dosing plan

  • Target maintenance dose can be achieved by starting with 3 breaths per session at week 1 and increasing by 1 breath per week until reaching 9-12 breaths per session1
  • Once the target maintenance dose is achieved, the patient should maintain that dose with each treatment session, as tolerated

6MWD=6-minute walk distance; AE=adverse event; LS=least squares; MMRM=mixed-effect model repeat measurement.