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TYVASO DPI IS NOW APPROVED

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FOR US HEALTHCARE PROFESSIONALS ONLY

For the treatment of pulmonary arterial hypertension (PAH) (WHO Group 1) to improve exercise ability.

FOR US HEALTHCARE PROFESSIONALS ONLY

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Dosing & Titration

Set your patients up for success with Tyvaso

Help patients understand the benefits and risks of therapy

1

ENSURE

PATIENTS UNDERSTAND THE DOSING PLAN

TYVASO FITS INTO YOUR PATIENT’S ROUTINE

TYVASO DPI (treprostinil) Inhalation Powder
TYVASO (treprostinil) Inhalation Solution
Portability

Small, portable device

Cordless flexibility

Setup

Insert single-dose cartridge and inhale1
Replace inhaler every 7 days1

Set up device 1x each morning3
Clean device 1x each night3

Dosing

4x daily1
1 breath per cartridge1
Each dose is inhaled in less than 2 seconds2

4x daily3
Multiple breaths per treatment session3
Each treatment session only takes approximately 2-3 minutes3

TYVASO DPI (treprostinil) Inhalation Powder
Portability
Small, portable device
Setup

Insert single-dose cartridge and inhale1
Replace inhaler every 7 days1

Dosing

4x daily1
1 breath per cartridge1
Each dose is inhaled in less than 2 seconds2

TYVASO (treprostinil) Inhalation Solution
Portability
Cordless flexibility
Setup

Set up device 1x each morning3
Clean device 1x each night3

Dosing

4x daily3
Multiple breaths per treatment session3
Each treatment session only takes approximately 2-3 minutes3

TREATMENT SESSIONS CAN BE SCHEDULED AROUND DAILY ACTIVITIES, APPROXIMATELY EVERY 4 WAKING HOURS1,3:

Tyvaso dosage approximate every 4 hoursTyvaso dosage approximate every 4 hours
2

SET

REALISTIC EXPECTATIONS

TYVASO DPI
TYVASO

The starting dose of TYVASO DPI is 16 mcg (1 breath per cartridge, 4x daily). Dosage should be increased by an additional 16 mcg per treatment session at approximately 1- to 2-week intervals. Titrate to target maintenance doses of 48 to 64 mcg per treatment session, 4x daily.1

Help patients achieve their target dose: 9-12 breaths, 4x daily.3

Dosing should be initiated at 3 breaths (18 mcg), 4x daily.3

TYVASO DPI titration scheduleTYVASO DPI titration schedule

If the prescribed dose is higher than 64 mcg per treatment session, more than 1 cartridge will be needed per session.1

TYVASO titration scheduleTYVASO titration schedule

AVERAGE TIME TO TARGET DOSE WAS ~3 WEEKS4

Patients can titrate with an additional 3 breaths per treatment session at 1- to 2-week intervals (as tolerated).3

TRIUMPH

72% of patients taking TYVASO achieved the target dose of 9 breaths, 4x daily4

TRIUMPH OLE

89% achieved 9 breaths, 4x daily3*

*42% achieved 12 breaths, 4x daily.3

TYVASO DPI

The starting dose of TYVASO DPI is 16 mcg (1 breath per cartridge, 4x daily). Dosage should be increased by an additional 16 mcg per treatment session at approximately 1- to 2-week intervals. Titrate to target maintenance doses of 48 to 64 mcg per treatment session, 4x daily.1

If the prescribed dose is higher than 64 mcg per treatment session, more than 1 cartridge will be needed per session.1

TYVASO

Help patients achieve their target dose: 9-12 breaths, 4x daily.3

Dosing should be initiated at 3 breaths (18 mcg), 4x daily.3

AVERAGE TIME TO TARGET DOSE WAS ~3 WEEKS4

Patients can titrate with an additional 3 breaths per treatment session at 1- to 2-week intervals (as tolerated).3

TRIUMPH

72% of patients taking TYVASO achieved the target dose of 9 breaths, 4x daily4

TRIUMPH OLE

89% achieved 9 breaths, 4x daily3*

*42% achieved 12 breaths, 4x daily.3

Titration schedules may vary based on tolerability.

Dose comparison1

Patients currently using the TYVASO nebulizer can be switched to the corresponding dose of TYVASO DPI:

TYVASO DPI Cartridge Strength
TYVASO Nebulizer # of Breaths
16 mcg
≤5
32 mcg
6 to 7
48 mcg
8 to 10
64 mcg
11 to 12
3

PREPARE

FOR COMMON AEs

AE MANAGEMENT APPROACHES

PREPARE YOUR PATIENTS FOR ADVERSE EVENTS

Prepare your patients for common adverse reactions with the following techniques:

MANAGING ADVERSE REACTIONS

Keep a daily activity diary and treatment tracker
Maintaining a daily activity diary and using the TYVASO Nebulizer Treatment Tracker can help your patients settle into a treatment routine while helping to document their good days and bad days. Remind your patients to bring both to each visit so you can review and check for compliance and signs of progress.

Specify your preferences on the Referral Form
Healthcare professionals can specify their preferences and directions for PRN medications on the Referral Form. To download the Referral Form, please click here.

Make an adverse reaction management plan
Give your patients specific instructions to help address adverse reactions. Select the methods that you feel are best for each patient.

MAKING AN ADVERSE EVENTS MANAGEMENT PLAN

Give your patients specific instructions to help manage adverse reactions. Below are some methods to consider for your patients.

The following approaches to managing adverse reactions are based on anecdotal evidence cited in Poms et al (2011)5 and should not be construed as medical advice. United Therapeutics does not recommend or endorse using healthcare products other than as directed or prescribed.

CONSIDERATIONS FOR ADVERSE REACTIONS5-7
Adverse Event
Management Approaches
Cough
  • Before treatment, drink very cold water or very warm water
  • Review proper technique for the prescribed device
  • Temporary dose reductions and/or slower titration
  • OTC or prescription cough medicines
Headache
  • OTC pain relievers
  • Temporary dose reductions
Throat Irritation
  • Oral analgesic spray

Remind patients to talk to you or your staff about any adverse reactions and not to discontinue treatment without your direction.

PATIENT SUPPORT